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Safety Assessment of Talc as Used in Cosmetics

Monice M Fiume1, Ivan Boyer2, Wilma F Bergfeld3

  • 1Cosmetic Ingredient Review Senior Scientific Analyst/Writer, Washington, DC, USA.

International Journal of Toxicology
|August 1, 2015
PubMed

Keywords:
cosmeticssafetytalc

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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