Gingerols and shogaols: Important nutraceutical principles from ginger
Ruchi Badoni Semwal1, Deepak Kumar Semwal1, Sandra Combrinck2
1Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.
Phytochemistry
|August 1, 2015
Summary
Gingerols and shogaols from ginger (Zingiber officinale) possess significant health benefits and diverse biological activities. This review explores their biosynthesis, synthesis, and therapeutic potential, particularly in cancer treatment.
Area of Science:
- Phytochemistry
- Pharmacology
- Nutraceutical Science
Background:
- Gingerols are key pungent compounds in ginger (Zingiber officinale Roscoe), known for health and nutritional benefits.
- Gingerols exhibit medicinal properties, including alleviating nausea, arthritis, and pain.
- Thermal degradation of gingerols yields shogaols, which also possess distinct pungent tastes and biological activities.
Purpose of the Study:
- To collate and summarize knowledge on gingerols and shogaols.
- To discuss their biosynthesis, chemical synthesis, and pharmacological activities.
- To explore their structure-activity relationships and therapeutic potential.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of biosynthesis and chemical synthesis pathways.
- Evaluation of pharmacological data and structure-activity relationships.
Main Results:
- Gingerols and shogaols display a wide range of biological activities, including anticancer, antioxidant, antimicrobial, anti-inflammatory, and CNS effects.
- Shogaols are crucial biomarkers for quality control in ginger products.
- Evidence suggests these phenolic compounds are potential lead molecules for therapeutic drug development.
Conclusions:
- Gingerols and shogaols show promise as therapeutic agents for various diseases, especially cancer.
- These compounds could be valuable in nutraceutical formulations for protection against diabetes, cardiac, and hepatic disorders.
- Further research into gingerols and shogaols can lead to novel treatments and health products.
Keywords:
Anti-inflammatoryAnticancerAntidiabeticGingerGingerolsNutraceuticalShogaolsZingiber officinaleMore Related Videos
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