Related Experiment Video
Updated: Jan 25, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
Published on: November 30, 2018
Triadin regulation of the ryanodine receptor complex
1Grenoble Institut des Neurosciences, Inserm U836, Université Joseph Fourier-Bat EJ Safra, Chemin Fortuné Ferrini, 38700, La Tronche, France.
Abstract:
The calcium release complex is the major player in excitation-contraction coupling, both in cardiac and skeletal muscle. The core of the complex is the ryanodine receptor, and triadin is a regulating protein. Nevertheless, the precise function of triadin is only partially understood. Besides its function in the anchoring of calsequestrin at the triad/dyad, our recent results allow us to propose hypotheses on new triadin scaffolding functions, based on the studies performed using different models, from triadin knockout mice to human patients, and expression in non-muscle cells, taking into account the presence of multiple triadin isoforms.
More Related Videos
Related Concept Videos
GTPases and their Regulation
Large G-proteins,...
Internal Receptors
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Positive Regulator Molecules
Master Transcription Regulators
Regulated mRNA Transport

