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Relationship between toothpastes properties and patient-reported discomfort: crossover study
Mariana Bruno1, Fernando Taddeo2, Igor Studart Medeiros2
1Master Degree Program, School of Dentistry, Ibirapuera University, Chácara Flora, São Paulo, Brazil.
Clinical Oral Investigations
|August 1, 2015
Summary
Low pH, abrasive, and cytotoxic toothpastes, like Oral B®, can cause patient irritation and sensitivity. Understanding toothpaste properties is crucial for minimizing adverse reactions and improving patient comfort.
Area of Science:
- Dental materials science
- In vitro toxicology
- Clinical oral health
Background:
- Toothpaste formulations vary widely in their chemical and physical properties.
- Patient-reported adverse reactions to toothpastes are common but often unlinked to specific product characteristics.
Purpose of the Study:
- To correlate patient-reported sensations with in vitro assessments of toothpaste pH, abrasivity, and cytotoxicity.
- To identify specific toothpaste properties that may lead to undesirable patient experiences.
Main Methods:
- 121 patients used non-identified toothpastes for 6 days and completed sensation questionnaires.
- In vitro analyses included pH measurement, composite resin abrasivity testing, and cytotoxicity assessment using MTT assay.
- Statistical analysis employed ANOVA/Tukey's tests to compare in vitro data.
Main Results:
- Oral B® toothpaste, excluding the bleaching variant, was associated with the highest incidence of irritation, tooth sensitivity, and taste/texture discomfort.
- In vitro findings revealed Oral B® had the lowest pH, highest abrasivity, and lowest cell viability.
- Significant correlations were observed between low pH, high abrasivity, cytotoxicity, and negative patient reports.
Conclusions:
- Toothpastes with low pH, high abrasivity, and significant cytotoxicity may induce adverse patient reactions.
- Knowledge of toothpaste properties is essential for clinicians to recommend products that minimize patient discomfort.
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