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Sclerosing Thymoma.
Deyali Chatterjee, Christie Jean Finch1
1From the Department of Pathology, Baylor College of Medicine, Houston, Texas.
Archives of Pathology & Laboratory Medicine
|August 1, 2015
Summary
Sclerosing thymoma is a rare anterior mediastinal mass. Complete surgical resection appears to be curative for this entity, highlighting the importance of its recognition in surgical pathology.
Area of Science:
- Pathology
- Oncology
- Thoracic Surgery
Background:
- Sclerosing thymoma is an extremely rare mediastinal neoplasm, with fewer than 15 cases reported.
- Its pathogenesis and biologic behavior remain largely uncertain.
- Characterized by extensive sclerosis, hyalinization, and calcification, with scant residual thymoma.
Purpose of the Study:
- To describe the clinicopathologic features of sclerosing thymoma.
- To emphasize the importance of recognizing this rare entity in the differential diagnosis of anterior mediastinal masses.
Main Methods:
- Case report of a recently diagnosed sclerosing thymoma.
- Review of existing literature on sclerosing thymoma.
Main Results:
- The diagnosed case presented as a large, well-circumscribed anterior mediastinal mass.
- Grossly, the mass had a homogeneously white-tan, solid cut surface without necrosis or hemorrhage.
- Microscopic examination revealed extensive sclerosis, hyalinization, and calcification.
Conclusions:
- Sclerosing thymoma is a distinct entity requiring recognition by surgical pathologists.
- Complete surgical resection has demonstrated curative potential in reported cases.
- Further research is needed to elucidate the pathogenesis and biologic behavior of sclerosing thymoma.
