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Recent advances in genome editing and creation of genetically modified pigs
James R Butler1, Joseph M Ladowski1, Gregory R Martens1
1Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
The field of xenotransplantation is benefiting greatly from recent advances in genetic engineering. The efficiency and pace with which new model animals are being created has dramatically sped progress towards clinical relevance. Endonuclease-driven genome editing now allows for the efficient generation of targeted genetic alterations. Herein we review the available methods of genetic engineering that have been successfully employed to create genetically modified pigs.
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