Combined isocyanide-based multi-component Ullmann-type reaction: an efficient access to novel nitrogen-containing
Shima Dianat1, Mohammad Mahdavi2, Setareh Moghimi2
1Department of Chemistry, Faculty of Science, Shahid Chamran University, Ahvaz, Iran.
Abstract:
2-Chloro-3-formyl quinoline has been applied as an aldehyde moiety in the Groebke-Blackburn-Bienaymé multi-component reaction with isocyanides, 2-aminoazines, and 2-aminoazole to afford the desired adducts which are amenable for further cyclization on the basis of Ullmann-type coupling. The copper iodide-mediated intramolecular C-N bond formation in the second step gave an easy access to a series of imidazo[4[Formula: see text],5[Formula: see text]:4,5]pyrrolo[2,3-b]quinoline derivatives in moderate to good yields.
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