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Primary myelofibrosis associated glomerulopathy: significant improvement after therapy with ruxolitinib

Arun Rajasekaran1, Thuy-Trang Ngo2, Maen Abdelrahim3

  • 1Department of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. arun.nephron@gmail.com.

BMC Nephrology
|August 2, 2015
PubMed
Abstract

Insights

Primary myelofibrosis (PMF) can cause early kidney damage, specifically MPN-related glomerulopathy. Prompt diagnosis and treatment improved kidney function in a patient with early-stage PMF.

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) causing bone marrow fibrosis and extramedullary hematopoiesis.
  • Renal involvement in PMF is uncommon, typically appearing as MPN-related glomerulopathy in advanced disease stages.

Observation:

  • This report details the first case of early renal glomerular involvement in PMF/MPN.
  • A 60-year-old male with PMF and stage 4 CKD presented with edema, AKI, and nephrotic-range proteinuria.

Findings:

  • Kidney biopsy revealed early MPN-related glomerulopathy, characteristic of the condition.
  • Early diagnosis and management stabilized kidney function to baseline levels.

Implications:

  • Further research is needed to identify risk factors and standardize treatment for MPN-related glomerulopathy.
  • Investigating whether aggressive PMF treatment impacts kidney disease progression is crucial.

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