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[REORGANIZATION OF THE ULTRASTRUCTURE OF NEOCORTICAL NEURONS IN RATS TREATED WITH CELL-FREE DNA].

L Ye Frumkina, I L Konorova, O P Aleksandrova

    Morfologiia (Saint Petersburg, Russia)
    |August 4, 2015
    PubMed
    Summary

    Intravenous or intraperitoneal injection of cell-free DNA induced significant ultrastructural changes in rat neocortical neurons. These changes suggest enhanced protein synthesis, synaptic transmission, and energy metabolism, potentially aiding recovery from brain injury.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Molecular Biology

    Context:

    • Investigating the effects of exogenous cell-free DNA (cfDNA) on neuronal structure.
    • Focusing on layers III-V of the rat brain neocortex.

    Purpose:

    • To examine the ultrastructural changes in neocortical neurons following cfDNA administration.
    • To understand the potential cellular mechanisms underlying cfDNA's impact on neuronal function.

    Summary:

    • Administration of cell-free DNA (cfDNA) via intraperitoneal or intravenous routes resulted in notable ultrastructural alterations in rat neocortical neurons.
    • Observed changes include nuclear chromatin restructuring, nucleolar hypertrophy, nuclear envelope invaginations, mitochondrial hyperplasia, and the formation of tubulovesicular bodies.
    • Astrocyte glia also showed signs of activation.

    Impact:

    • The observed neuronal reorganization suggests enhanced protein synthesis and synaptic transmission efficiency.
    • Increased energy metabolism indicates a potential role for cfDNA in supporting reparative and compensatory processes in cerebral ischemic conditions.