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PCC characteristics at rest in 10-year memory decliners.

Charlotte Bernard1, Bixente Dilharreguy2, Catherine Helmer3

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Summary
This summary is machine-generated.

This study reveals altered brain network function in elderly individuals with memory decline, particularly in the posterior cingulate cortex. These changes may indicate a risk for Alzheimer's disease.

Keywords:
AgingGraph theoryMemory declineNBSPCCResting-state fMRI

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Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Neuroimaging

Background:

  • Episodic memory decline is a common concern in the elderly.
  • Understanding the neural underpinnings of memory decline is crucial for early intervention.
  • Longitudinal studies are essential for tracking cognitive changes over time.

Purpose of the Study:

  • To characterize intrinsic functional brain networks associated with a 10-year episodic memory decline in the elderly.
  • To compare the functional architecture of brain networks at connectional and topological levels between individuals with and without memory decline.
  • To identify specific brain regions and networks implicated in age-related memory impairment.

Main Methods:

  • Utilized data from a longitudinal population-based cohort (Bordeaux-3City).
  • Employed whole-brain resting-state functional magnetic resonance imaging (fMRI).
  • Assessed episodic memory decline using the Free and Cued Selective Reminding Test over multiple time points.

Main Results:

  • Individuals with memory decline showed altered functional architecture centered on the posterior cingulate cortex.
  • A significant decrease in connectivity intensity and increased centrality were observed in the posterior cingulate cortex of decliners.
  • Reduced functional connectivity within the default mode network was evident in those experiencing memory decline.

Conclusions:

  • The posterior cingulate cortex plays a central role in slow, reliable memory decline in the elderly.
  • The identified functional signature in the posterior cingulate cortex may represent a risk factor for Alzheimer's disease.
  • Functional alterations in this region warrant further investigation as potential biomarkers for Alzheimer's disease risk.