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Effect of Percutaneous Coronary Intervention on Left Ventricular Diastolic Function in Patients With Coronary Artery

Nahid Salehi, Mohammadreza Saidi, Alireza Rai

  • 1Medical Students Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. h_tadbiri@student.tums.ac.ir.

Global Journal of Health Science
|August 4, 2015
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly improved left ventricular diastolic function in patients with coronary artery disease (CAD). The E/Ea ratio, a key indicator of diastolic heart failure (DHF), showed marked improvement three months post-PCI.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Medical Interventions

Background:

  • Disagreement exists regarding percutaneous coronary intervention (PCI) effects on left ventricular diastolic function.
  • Diastolic indices require thorough investigation in coronary artery disease (CAD) patients undergoing PCI.
  • This study evaluates diastolic function changes three months post-PCI in CAD patients.

Purpose of the Study:

  • To assess left ventricular diastolic function and its indices after PCI.
  • To determine the impact of PCI on diastolic heart failure (DHF) criteria.
  • To evaluate changes in key diastolic indices like E/Ea.

Main Methods:

  • A quasi-experimental, before-and-after clinical trial was conducted.
  • 51 CAD patients with Ejection Fraction (EF) > 30% scheduled for elective PCI were included.
  • Echocardiography assessed left ventricular diastolic indices, including E/Ea, before and three months after PCI.

Main Results:

  • The prevalence of DHF decreased significantly post-PCI (78.4% to 54.9%, p<0.05), based on E/Ea.
  • Significant changes were observed in deceleration time (DT), isovolumic relaxation time (IVRT), early diastolic mitral annulus velocity (Ea), E/Ea, and left ventricular ejection function (LVEF).
  • Gender-specific significant changes were noted in MVA dur/PVA dur, PVs/PVd, and E/Ea indices.

Conclusions:

  • PCI improved the E/Ea ratio, a critical diagnostic marker for DHF.
  • Several other diastolic indices demonstrated improvement following the PCI procedure.
  • PCI is an effective treatment for enhancing left ventricular diastolic function in CAD patients.
Abstract

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