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Antimicrobial Susceptibility/Resistance of Streptococcus Pneumoniae

Emina Karcic1, Mufida Aljicevic2, Sabaheta Bektas3

  • 1Department of Pediatrics, Cantonal hospital, Zenica, Bosnia and Herzegovina.

Materia Socio-Medica
|August 4, 2015
PubMed
Abstract

Insights

Pneumococcal infections are a growing threat due to antibiotic resistance. This study found high resistance to erythromycin, clindamycin, and trimethoprim-sulfamethoxazole in Streptococcus pneumoniae, indicating these should be avoided in treatment.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Pneumococcal infections pose a significant global health burden.
  • Increasing antibiotic resistance in Streptococcus pneumoniae strains complicates treatment.
  • Antimicrobial resistance threatens the efficacy of current therapeutic strategies.

Purpose of the Study:

  • To investigate the antimicrobial susceptibility and resistance patterns of Streptococcus pneumoniae (S. pneumoniae).
  • To identify prevalent resistance mechanisms in clinical isolates.
  • To inform empirical treatment guidelines for pneumococcal infections.

Main Methods:

  • Collection of clinical samples including nasal, nasopharyngeal, eye, and ear swabs.
  • In vitro antimicrobial susceptibility testing using disk diffusion and E-test methods.
  • Evaluation of resistance against various antibiotic classes, including cell wall synthesis inhibitors, protein synthesis inhibitors, folate antagonists, and quinolones.

Main Results:

  • High resistance rates were observed for folate antagonists (47.78%) and cell wall synthesis inhibitors (39.17%).
  • Specific drug resistance included erythromycin (45%), clindamycin (45%), and oxacillin (73.89%).
  • Low resistance was noted for tetracycline (4.67%), penicillin-G (4.44%), and ciprofloxacin (1.11%).

Conclusions:

  • Streptococcus pneumoniae exhibits significant resistance to erythromycin, clindamycin, and trimethoprim-sulfamethoxazole.
  • These antibiotics should be used with caution or avoided in treating resistant pneumococcal infections.
  • Tetracycline, rifampicin, chloramphenicol, penicillin-G, and ciprofloxacin demonstrated lower resistance rates.
Keywords:
antibioticspneumococcusresistancesusceptibility

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