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Replication - why we need to publish our findings.

Michael J Curtis1, Darrell R Abernethy2

  • 1Cardiovascular Division, King's College London, Rayne Institute, St Thomas' Hospital London, SE17EH, United Kingdom.

Pharmacology Research & Perspectives
|August 4, 2015
PubMed
Summary

This special issue of Pharmacology Research and Perspectives (PR&P) addresses the need for greater transparency and improved standards in pharmacological research. It highlights initiatives to publish replication and negative findings, enhancing research reliability.

Keywords:
Experimental designreplication

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Area of Science:

  • Pharmacology
  • Scientific Publishing
  • Research Integrity

Background:

  • The pharmacology research sector faces increasing demands for transparency and higher standards.
  • Pharmacology Research and Perspectives (PR&P) is adapting to these evolving needs.
  • Publication bias towards positive findings is a significant challenge in scientific research.

Purpose of the Study:

  • To outline how PR&P is responding to the call for greater transparency and better standards in pharmacology.
  • To present strategies for improving the reliability of pharmacological research publications.
  • To encourage the submission and publication of replication and negative findings.

Main Methods:

  • This issue features three articles addressing research reliability.
  • The first article discusses the importance and encouragement of replication studies.
  • The second explores initiatives for publishing negative clinical findings, including a PR&P program.
  • The third article introduces a toolkit for enhancing drug discovery research reliability.

Main Results:

  • PR&P actively encourages the submission of replication studies to counteract publication bias.
  • Initiatives are being developed to facilitate the publication of negative clinical findings.
  • A toolkit is available to improve the reliability of findings in drug discovery research.

Conclusions:

  • PR&P is committed to enhancing transparency and reliability in pharmacological research.
  • Encouraging replication and negative findings is crucial for scientific progress.
  • Implementing robust toolkits can significantly improve the integrity of drug discovery research.