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Advancing safety pharmacology: Emerging technologies, innovative methods, and future directions
Michael K Pugsley1, Brett R Winters1, Lutfiya Miller2
1Toxicology & Safety Pharmacology, Cytokinetics, South San Francisco, CA 94080, USA.
Journal of Pharmacological and Toxicological Methods
|July 29, 2026
Summary
This editorial highlights advancements in safety pharmacology methods, focusing on core battery evaluations and emerging AI applications. It emphasizes the critical role of methodological innovation in drug safety assessment.
Area of Science:
- Pharmacology
- Toxicology
- Drug Safety
Background:
- The Journal of Pharmacological and Toxicological Methods (JPTM) annual themed issue focuses on safety pharmacology.
- Content is derived from the 2025 Safety Pharmacology Society Annual Meeting, featuring 124 posters.
Purpose of the Study:
- To introduce and summarize recent methodological advancements in safety pharmacology.
- To highlight key areas of innovation presented at the annual meeting.
Main Methods:
- Review of manuscripts and abstracts presented at the Safety Pharmacology Society Annual Meeting.
- Focus on core battery safety evaluations and data analysis.
- Exploration of emerging areas like AI and digital monitoring.
Main Results:
- Advances in core battery safety evaluations and data analysis methodologies.
- Emerging areas include AI, digital monitoring, advanced in vitro assays, and alternative hERG assays (IC10 vs. IC50).
Conclusions:
- The ongoing themed issues demonstrate the sustained importance of methodological innovation in safety pharmacology.
- Safety pharmacology plays a pivotal role in advancing drug safety assessment methodologies.
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