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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
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Layered Double Hydroxide Assemblies with Controllable Drug Loading Capacity and Release Behavior as well as
Fengzhu Lv1, Linan Xu1, Yihe Zhang1
1Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences , Beijing, 100083, China.
ACS Applied Materials & Interfaces
|August 4, 2015
Summary
Researchers developed a stable, magnetically targeted drug delivery system using layered double hydroxide assemblies. These novel assemblies offer controlled drug release and show great potential for advanced therapeutic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Developing stable drug delivery systems with magnetic targeting capabilities is crucial for effective therapeutic interventions.
- Layered double hydroxides (LDHs) and magnetic nanoparticles offer promising properties for drug delivery applications.
- Controlling drug release kinetics and ensuring system stability are key challenges in drug delivery research.
Purpose of the Study:
- To fabricate and characterize novel layered double hydroxide assemblies for magnetically targeted drug delivery.
- To investigate the stability, drug loading capacity, and release behavior of the developed assemblies.
- To evaluate the magnetic properties and potential of these multifunctional assemblies for drug delivery systems.
Main Methods:
- Layer-by-layer assembly of poly(allylamine hydrochloride) and poly(acrylic acid) on Fe3O4 and ZnAl-LDH composite particles.
- Covalent cross-linkage of polymer multilayers using a photosensitive cross-linker.
- Characterization using Zeta potential and Fourier transform infrared spectroscopy.
- Assessment of stability in varying pH conditions and drug release studies using methylene blue.
- Evaluation of magnetic properties and response to external magnetic fields.
Main Results:
- Successfully fabricated stable layered double hydroxide assemblies with polymer multilayers.
- Assemblies demonstrated stability in alkaline conditions (pH > 7).
- Drug loading and release were controllable via acidic treatment, confirmed with methylene blue.
- Assemblies exhibited significant magnetic strength and sensitivity to external magnetic fields, enabling targeting.
- The system showed multifunctionality with high potential for drug delivery.
Conclusions:
- The developed layered double hydroxide assemblies are stable and possess magnetic targeting capabilities.
- These assemblies allow for controlled drug loading and release, adaptable to specific therapeutic needs.
- The system's magnetic responsiveness and multifunctionality highlight its significant potential as an advanced drug delivery platform.
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