Related Experiment Video

Updated: Apr 6, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.7K

Continuous Veno-Venous Hemodiafiltration and Plasma Exchange in Infantile Acute Liver Failure

Kentaro Ide1, Takashi Muguruma, Mafumi Shinohara

  • 11Department of Critical Care and Anesthesia, National Center for Child Health and Development, Tokyo, Japan. 2Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|August 4, 2015
PubMed

Insights

This study shows a multidisciplinary approach, including intensive care and liver support, significantly improves outcomes for infants with acute liver failure. The treatment strategy led to high survival and good neurological recovery rates in young patients.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Critical Care Medicine

Background:

  • Acute liver failure (ALF) in infants presents significant challenges.
  • Multidisciplinary care is crucial for managing complex pediatric cases.
  • Timely intervention, including liver support and transplantation, is vital.

Purpose of the Study:

  • To evaluate a comprehensive strategy for infants with ALF.
  • The approach integrates neurology-focused intensive care, artificial liver support, and timely liver transplantation.
  • To assess the effectiveness of this combined treatment protocol.

Main Methods:

  • Retrospective cohort study of 17 infants (<12 months) with ALF.
  • Patients received neurology-oriented intensive care and continuous veno-venous hemodiafiltration + plasma exchange.
  • All underwent living-donor liver transplantation between 2006 and 2011.

Main Results:

  • Significant improvements in bilirubin, ammonia, coagulation, and creatinine levels were observed post-artificial liver support (p < 0.001).
  • The overall survival rate was 88% (15/17) with a median follow-up of 28 months.
  • Among survivors, 73% had no neurological morbidities, and 20% had mild disabilities.

Conclusions:

  • A multidisciplinary approach combining intensive care, artificial liver support, and liver transplantation yields favorable outcomes in infants with ALF.
  • The strategy demonstrated high survival and positive neurological recovery.
  • Further research is warranted to specifically evaluate the efficacy of artificial liver support systems.
Abstract

More Related Videos

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

17.0K
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

13.3K

Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
354
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
338
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
2.0K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
481
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.3K
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
903