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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Therapies02:49

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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Treatment Resistent Cancers02:56

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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Apr 6, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

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[Oncologic therapy of soft tissue sarcoma].

Maija Tarkkanen, Paula Lindholm, Anna-Stina Jääskeläinen

    Duodecim; Laaketieteellinen Aikakauskirja
    |August 5, 2015
    PubMed
    Summary

    Complete treatment for soft tissue sarcoma involves surgery with clear margins. Multidisciplinary teams are crucial for managing rare soft tissue sarcoma cases, utilizing surgery, radiotherapy, and chemotherapy to improve outcomes and patient care.

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Radiation Oncology
    • Medical Oncology

    Context:

    • Soft tissue sarcoma is a rare malignancy requiring specialized treatment approaches.
    • Current treatment paradigms focus on achieving curative resection with adequate margins.

    Purpose:

    • To outline the curative and adjuvant treatment modalities for soft tissue sarcoma.
    • To emphasize the importance of a multidisciplinary team in managing these rare tumors.

    Summary:

    • Surgery with a margin of resection is the primary curative treatment for soft tissue sarcoma.
    • Combining surgery with radiotherapy can reduce local recurrence risk, especially when wide margins are challenging.
    • Combination chemotherapy may decrease disease recurrence in high-risk patients.

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  • Radiotherapy offers palliative symptom relief.

    • Impact:

    • Optimizing treatment strategies through multidisciplinary collaboration can improve outcomes for soft tissue sarcoma patients.
    • Preserving limb function while managing local recurrence is a key consideration in treatment planning.