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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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[Adverse cardiac effects associated with anticancer drugs]
Duodecim; Laaketieteellinen Aikakauskirja
|August 5, 2015
Summary
Cancer treatments, including new targeted therapies and older cytotoxic drugs, can impact heart health. Some drugs may cause cardiac issues like heart failure or high blood pressure years after treatment.
Area of Science:
- Oncology and Cardiology
- Pharmacology and Therapeutics
Context:
- Recent advancements in cancer treatment involve novel protein kinase inhibitors, immunomodulators, and hormonal therapies.
- Traditional cytotoxic chemotherapy agents remain integral to cancer management strategies.
- Cardiotoxicity is a significant concern associated with various cancer therapeutics.
Purpose:
- To review the cardiotoxic effects of both novel and established cancer treatments.
- To highlight specific cardiac adverse events associated with different drug classes used in cancer therapy.
Summary:
- Newer cancer drugs like trastuzumab and kinase inhibitors, alongside traditional anthracyclines, can lead to heart failure, sometimes with delayed onset.
- Fluoropyrimidines may induce myocardial ischemia, while VEGF inhibitors frequently cause hypertension.
- Understanding these cardiac risks is crucial for patient management and monitoring during cancer treatment.
Impact:
- Informing oncologists and cardiologists about potential cardiac complications.
- Guiding clinical practice for safer and more effective cancer therapy.
- Improving patient outcomes by proactively managing treatment-related cardiotoxicity.
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