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Children Experiencing First-Time or Prolonged Febrile Seizure Are Prone to Stress Hyperglycemia

Jeong-Yong Lee1, Jung-Heon Kim1, Hyung-Rae Cho1

  • 1Department of Pediatrics, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.

Journal of Child Neurology
|August 5, 2015
PubMed

Insights

Stress hyperglycemia, a condition of high blood glucose, affects 10% of children with febrile seizures. First-time and prolonged seizures are key risk factors, indicating a link to seizure severity.

Area of Science:

  • Pediatrics
  • Neurology
  • Endocrinology

Background:

  • Stress hyperglycemia in children with febrile seizures is not well understood.
  • Its prevalence and associated risk factors require further investigation.

Purpose of the Study:

  • To determine the prevalence of stress hyperglycemia in children with febrile seizures.
  • To identify risk factors and clinical implications of stress hyperglycemia in this population.

Main Methods:

  • A study involving 479 children diagnosed with febrile seizures.
  • Analysis of blood glucose levels, pH, and lactate.
  • Multivariate analysis to identify risk factors.

Main Results:

  • The prevalence of stress hyperglycemia (blood glucose ≥ 150 mg/dL) was 10.0%.
  • First-time and prolonged febrile seizures were significant risk factors (aOR = 3.741 and 12.855, respectively).
  • The stress hyperglycemia group showed lower pH and higher lactate levels, suggesting increased seizure severity.

Conclusions:

  • Children with first-time or prolonged febrile seizures are more susceptible to stress hyperglycemia.
  • Stress hyperglycemia may be associated with febrile seizure severity but does not predict early recurrence.

Keywords:
childrenfebrile seizurerecurrencerisk factorstress hyperglycemia

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