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Related Experiment Video

Updated: Apr 6, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

[Drug related colonic perforation: Case report].

Edgar Núñez-García¹, Luis César Valencia-García¹, Ricardo Sordo-Mejía¹

¹Servicio de Cirugía General, Centro Médico ABC, México D.F. , México.

Cirugia Y Cirujanos

|August 6, 2015

Summary

Polypharmacy can lead to acute colonic pseudo-obstruction, a serious condition causing intestinal perforation. Early detection of drug interactions is crucial to prevent severe complications.

Keywords:

Colonic pseudo-obstruction Drugs Fármacos Intestinal perforation Multiple medications Perforación intestinal Polifarmacia Pseudo-obstrucción colónica

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Area of Science:

Gastroenterology
Clinical Pharmacology

Background:

Acute colonic pseudo-obstruction involves increased intra-luminal pressure, leading to intestinal ischemia and necrosis.
The exact cause is unknown but linked to trauma, anesthesia, or autonomic nervous system-altering drugs.
Medication-induced colon toxicity can result in perforation and mortality.

Purpose of the Study:

To present a case of colonic pseudo-obstruction solely due to polypharmacy.
To review the literature on treating this condition.

Main Methods:

A case report of a 67-year-old woman with acute colonic pseudo-obstruction.
Symptoms included abdominal pain, distension, fever, and tachycardia.
Radiological studies revealed free intraperitoneal air, indicating perforation.

Main Results:

The patient's only identified risk factor was polypharmacy.
The condition progressed to intestinal perforation, necessitating surgical intervention.
Surgical treatment successfully resolved the pseudo-obstruction and perforation.

Conclusions:

Drug interactions are a significant risk factor for severe gastrointestinal complications.
Considering polypharmacy in patients with multiple comorbidities is vital for timely diagnosis and prevention of adverse outcomes.