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Updated: Apr 6, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
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[Drug related colonic perforation: Case report]
Edgar Núñez-García1, Luis César Valencia-García1, Ricardo Sordo-Mejía1
1Servicio de Cirugía General, Centro Médico ABC, México D.F. , México.
Cirugia Y Cirujanos
|August 6, 2015
Summary
Polypharmacy can lead to acute colonic pseudo-obstruction, a serious condition causing intestinal perforation. Early detection of drug interactions is crucial to prevent severe complications.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Acute colonic pseudo-obstruction involves increased intra-luminal pressure, leading to intestinal ischemia and necrosis.
- The exact cause is unknown but linked to trauma, anesthesia, or autonomic nervous system-altering drugs.
- Medication-induced colon toxicity can result in perforation and mortality.
Purpose of the Study:
- To present a case of colonic pseudo-obstruction solely due to polypharmacy.
- To review the literature on treating this condition.
Main Methods:
- A case report of a 67-year-old woman with acute colonic pseudo-obstruction.
- Symptoms included abdominal pain, distension, fever, and tachycardia.
- Radiological studies revealed free intraperitoneal air, indicating perforation.
Main Results:
- The patient's only identified risk factor was polypharmacy.
- The condition progressed to intestinal perforation, necessitating surgical intervention.
- Surgical treatment successfully resolved the pseudo-obstruction and perforation.
Conclusions:
- Drug interactions are a significant risk factor for severe gastrointestinal complications.
- Considering polypharmacy in patients with multiple comorbidities is vital for timely diagnosis and prevention of adverse outcomes.
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