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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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Coeliac disease in children.

Siba Prosad Paul1, Emily Natasha Kirkham2, Sarah Pidgeon1

  • 1Bristol Royal Hospital for Children, Bristol, England.

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|August 6, 2015
PubMed
Summary

Coeliac disease, an immune disorder triggered by gluten, can manifest with various gastrointestinal and extra-intestinal symptoms. Diagnosis involves serological screening and potentially biopsy, with a strict gluten-free diet being the primary management strategy.

Keywords:
Allergyanaemiachildren’s nursingcoeliac diseasedietitiangluten-free diethuman leucocyte antigeniron deficiencypaediatricssmall bowel biopsyvitamin D

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Area of Science:

  • Immunology
  • Gastroenterology
  • Pediatrics

Background:

  • Coeliac disease is an immune-mediated systemic disorder triggered by gluten ingestion.
  • It classically presents with gastrointestinal symptoms but can also cause extra-intestinal manifestations.
  • Certain groups, including those with a family history or genetic disorders, are at higher risk.

Purpose of the Study:

  • To outline the diagnostic criteria and management strategies for coeliac disease in children.
  • To highlight the importance of recognizing varied clinical presentations for timely diagnosis.
  • To inform healthcare professionals about updated diagnostic guidelines.

Main Methods:

  • Serological screening using anti-tissue transglutaminase titres.
  • Confirmation via small bowel biopsy (traditionally required).
  • Application of modified European guidelines for diagnosis without biopsy in specific cases (high antibody titres, HLA-DQ2/DQ8 positive).

Main Results:

  • Modified guidelines allow diagnosis without biopsy in symptomatic children with high anti-tissue transglutaminase titres and positive HLA-DQ2 or HLA-DQ8 status.
  • Strict adherence to a lifelong gluten-free diet leads to symptom resolution and prevents long-term complications.
  • Awareness of diverse presentations is crucial for early detection.

Conclusions:

  • Coeliac disease diagnosis can be streamlined in specific pediatric cases, potentially avoiding invasive procedures.
  • Lifelong gluten-free diet is essential for managing coeliac disease and its complications.
  • Healthcare providers must be vigilant for varied coeliac disease presentations to ensure prompt management.