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Criteria for reference value assessment of elements in human tissues
Annali Dell'Istituto Superiore Di Sanita
|January 1, 1989
Summary
Establishing reliable reference values for elements in biological samples is crucial for accurate clinical and environmental studies. This study outlines analytical principles to standardize elemental data, reducing variability in reported normal intervals.
Area of Science:
- Analytical Chemistry
- Environmental Science
- Clinical Diagnostics
Background:
- Accurate reference values for elements in biological tissues and fluids are essential for clinical, toxicological, and environmental research.
- Current scientific literature shows wide variations in reported "normal" elemental intervals.
- Standardized analytical approaches are needed to improve data reliability.
Purpose of the Study:
- To outline basic principles for a proper analytical approach to obtain reliable elemental reference values.
- To reduce the wide range of figures reported for elemental "normal" intervals.
- To assess tentative reference values for specific elements in human organs.
Main Methods:
- Outlined basic principles for analytical procedures.
- Applied guidelines to human lung, liver, and kidney tissues.
- Assessed reference values for minor and trace elements (Al, Ba, Cd, Cr, Cu, Li, Mg, Mn, Pb, Sr, V, Zn).
Main Results:
- Provided a framework for obtaining updated and reliable elemental reference values.
- Demonstrated the application of these principles to human organs.
- Established tentative reference values for selected elements in human lungs, liver, and kidneys.
Conclusions:
- Adherence to outlined analytical principles can lead to more consistent and reliable elemental reference values.
- Standardized data will improve the accuracy of clinical, toxicological, and environmental studies.
- Tentative reference values for key elements in human organs are now available.