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Clonal evolution: multiregion sequencing of esophageal adenocarcinoma before and after chemotherapy
Siddhartha Devarakonda1, Ramaswamy Govindan2
1Division of Medical Oncology, Washington University School of Medicine, St. Louis, Missouri.
Cancer Discovery
|August 6, 2015
Abstract:
It is possible to decipher the clonal architecture of a tumor and the sequence in which cancer clones acquire genomic alterations through multiregion sequencing (M-seq). Serial evaluation of tumor specimens through M-seq can provide valuable information on the molecular basis of resistance to therapy.

