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Updated: Apr 5, 2026

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
Published on: June 15, 2011
Venous thromboembolism and coffee: critical review and meta-analysis
Giuseppe Lippi1, Camilla Mattiuzzi1, Massimo Franchini1
11 Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy ; 2 Service of Clinical Governance, General Hospital of Trento, Trento, Italy ; 3 Department of Hematology and Transfusion Medicine, C. Poma Hospital, Mantova, Italy.
Background:
Among the various risk factors of venous thromboembolism (VTE), nutrients seem to play a significant role in the pathogenesis of this condition. This study aimed to clarify the relationship between coffee intake and venous thrombosis, and we performed a critical review of clinical studies that have been published so far.
Methods:
An electronic search was carried out in Medline, Scopus and ISI Web of Science with the keywords "coffee" AND "venous thromboembolism" OR "deep vein thrombosis" OR "pulmonary embolism" in "Title/Abstract/Keywords", with no language and date restriction.
Results:
According to our criteria, three studies (two prospective and one case-control) were finally selected (inter-study heterogeneity: 78%; P<0.001). Cumulative data suggests that a modest intake of coffee (i.e., 1-4 cups/day) may be associated with an 11% increased risk of VTE compared to abstainers, whereas a larger intake (i.e., ≥5 coffee/day) may be associated with a 25% decreased risk.
Conclusions:
Our analysis of published data seemingly confirm the existence of a U-shape relationship between coffee intake and VTE, thus exhibiting a trend that overlaps with that previously reported for cardiovascular disease (CVD).
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