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Primary capsule-deficient cutaneous cryptococcosis in a sporotrichoid pattern in an immunocompetent host

Nathan Am Jackson1, Daniel B Herring

  • 111007 Blan Avon Rd, Midlothian, MD 21543, USA. njackson@osteo.wvsom.edu.

Cutis
|August 6, 2015
PubMed

Insights

Primary cutaneous cryptococcosis (PCC) is a rare fungal skin infection. This case highlights a unique instance of PCC in an immunocompetent elderly patient, challenging typical disease associations.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Cryptococcosis is a significant opportunistic infection, primarily affecting immunocompromised individuals.
  • It is commonly caused by Cryptococcus neoformans and frequently manifests as meningitis.
  • Primary cutaneous cryptococcosis (PCC) is an uncommon variant, localized to the skin without systemic spread.

Observation:

  • A rare case of primary cutaneous cryptococcosis (PCC) is presented.
  • The patient was a 73-year-old male with preserved cell-mediated immunity.
  • Clinical presentation included skin lesions resembling a whitlow or phlegmon.

Findings:

  • Culture results confirmed the presence of Cryptococcus neoformans in the skin lesions.
  • No evidence of simultaneous dissemination to other organs was detected.
  • The patient's intact immune system was a notable factor in this rare presentation.

Implications:

  • This case expands the understanding of Cryptococcus neoformans' clinical spectrum.
  • It suggests that PCC can occur even in individuals with robust immune systems.
  • Further research may elucidate specific host or fungal factors contributing to PCC in immunocompetent hosts.

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