[Innervation density in the stroma and the muscular tunica in biopsies of the normal and pathologic bladder]

Twenty-eight open urinary bladder biopsies were stained using a peroxidase-antiperoxidase technique for S100 to demonstrate the innervation pattern in three different patient groups. The nerve profiles in the subepithelial stroma and in the musculosa were counted and compared. There was a definite correlation between nerve density in both layers. Examination of superficial bladder biopsies is reliable in the assessment of the innervation pattern of neurogenic and non-neurogenic bladder disorders.