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Updated: Apr 5, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Translational Scholarship and a Palliative Approach: Enlisting the Knowledge-As-Action Framework
Sheryl Reimer-Kirkham1, Gweneth Hartrick Doane, Elisabeth Antifeau
1School of Nursing, Trinity Western University, British Columbia, Canada (Dr Reimer-Kirkham); School of Nursing, University of Victoria, British Columbia, Canada (Drs Doane and Stajduhar); Interior Health Authority, British Columbia, Canada (Ms Antifeau); School of Nursing, University of British Columbia, Canada (Dr Pesut and Ms Porterfield); and Fraser Health Authority, British Columbia, Canada (Mss Roberts and Wikjord).
This study introduces the Knowledge-As-Action Framework to address the know-do gap in knowledge translation (KT). The framework, using a kite metaphor, helps manage complex KT projects by viewing knowledge and action as interconnected.
Area of Science:
- Health Services Research
- Knowledge Translation
- Implementation Science
Background:
- The persistent
- know-do gap
- hinders effective implementation of evidence-based practices.
- Traditional approaches often separate knowing from doing, failing to capture the dynamic nature of knowledge translation (KT).
Purpose of the Study:
- To describe the application of the Knowledge-As-Action Framework, a novel approach to KT.
- To illustrate how this framework addresses the complexities inherent in knowledge translation processes.
- To demonstrate the interconnectedness of key dimensions within KT projects.
Main Methods:
- Application of the Knowledge-As-Action Framework as a heuristic device.
- Utilizing a kite metaphor to conceptualize the KT process.
- Analysis of a KT demonstration project integrating a palliative approach across three clinical sites.
Main Results:
- The Knowledge-As-Action Framework facilitated a responsive approach to KT complexities.
- The kite metaphor effectively illustrated the dynamic and interconnected nature of KT.
- The demonstration project highlighted the interplay of local context, processes, people, knowledge, fluctuating realities, and values.
Conclusions:
- The Knowledge-As-Action Framework offers a valuable tool for understanding and navigating complex KT initiatives.
- Conceptualizing knowledge and action as inseparable is crucial for successful evidence implementation.
- The framework's dimensions provide a comprehensive lens for analyzing KT projects.
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