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Updated: Apr 5, 2026

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
Published on: December 9, 2018
[Licorice as the cause of elevated blood pressure and headache?]
Abstract:
Physicians are familiar with the effect on potassium metabolism of glycyrrhizine acid contained in licorice and salmiac. Even so, glycyrrhizine acid as the cause of even severe symptoms may escape attention, especially in an emergency situation. We describe a patient, who sought medical advice from an endocrinologist for recurrent, severe and symptomatic hypertension. After the patient had stopped eating salmiac and licorice, the headache that had persisted for years disappeared, fluctuations in weight stabilized and occasional edemas of the lower limbs vanished. Since the cessation of using licorice products normalized the blood pressure, it is likely that the patient had licorice-induced hypertension.
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