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Bone and bone marrow involvement in sarcoidosis
Ralph Yachoui1, Brian J Parker2, Thanhcuong T Nguyen3
1Department of Rheumatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, WI, 54449, USA. yachoui.ralph@marshfieldclinic.org.
Rheumatology International
|August 8, 2015
Summary
Osseous sarcoidosis, affecting bones and bone marrow, is uncommon but increasingly recognized. Advanced imaging like FDG-PET aids in detecting widespread skeletal involvement.
Area of Science:
- Rheumatology
- Oncology
- Radiology
Background:
- Sarcoidosis is a multisystem inflammatory disease of unknown etiology.
- Osseous and bone marrow involvement in sarcoidosis are rare, with limited case reports.
- This study focuses on the clinical, radiological, and pathological aspects of skeletal sarcoidosis.
Observation:
- Presents a case series of three patients with osseous sarcoidosis and one with bone marrow sarcoidosis.
- Utilizes fluorodeoxyglucose positron emission tomography (FDG-PET) for whole-body staging.
- Highlights findings from clinical evaluation, radiological imaging, and pathological examination.
Findings:
- Osseous sarcoidosis can manifest with diverse clinical and radiological features.
- FDG-PET is valuable for assessing the extent of skeletal sarcoidosis.
- Large bone and axial skeleton lesions are more frequently identified with modern imaging techniques.
Implications:
- Increased recognition of osseous sarcoidosis is necessary for timely diagnosis and management.
- Advanced imaging modalities improve the detection and characterization of skeletal sarcoidosis.
- Further research is warranted to understand the pathogenesis and optimize treatment strategies for osseous sarcoidosis.
Keywords:
BoneBone diseasesBone marrowGranulomaLymph nodesRadiographyRadionuclide imagingSarcoidosis/diagnosisSarcoidosis/etiologyMore Related Videos
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