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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
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Bone and bone marrow involvement in sarcoidosis.

Ralph Yachoui1, Brian J Parker2, Thanhcuong T Nguyen3

  • 1Department of Rheumatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, WI, 54449, USA. yachoui.ralph@marshfieldclinic.org.

Rheumatology International
|August 8, 2015
PubMed
Summary

Osseous sarcoidosis, affecting bones and bone marrow, is uncommon but increasingly recognized. Advanced imaging like FDG-PET aids in detecting widespread skeletal involvement.

Keywords:
BoneBone diseasesBone marrowGranulomaLymph nodesRadiographyRadionuclide imagingSarcoidosis/diagnosisSarcoidosis/etiology

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Area of Science:

  • Rheumatology
  • Oncology
  • Radiology

Background:

  • Sarcoidosis is a multisystem inflammatory disease of unknown etiology.
  • Osseous and bone marrow involvement in sarcoidosis are rare, with limited case reports.
  • This study focuses on the clinical, radiological, and pathological aspects of skeletal sarcoidosis.

Observation:

  • Presents a case series of three patients with osseous sarcoidosis and one with bone marrow sarcoidosis.
  • Utilizes fluorodeoxyglucose positron emission tomography (FDG-PET) for whole-body staging.
  • Highlights findings from clinical evaluation, radiological imaging, and pathological examination.

Findings:

  • Osseous sarcoidosis can manifest with diverse clinical and radiological features.
  • FDG-PET is valuable for assessing the extent of skeletal sarcoidosis.
  • Large bone and axial skeleton lesions are more frequently identified with modern imaging techniques.

Implications:

  • Increased recognition of osseous sarcoidosis is necessary for timely diagnosis and management.
  • Advanced imaging modalities improve the detection and characterization of skeletal sarcoidosis.
  • Further research is warranted to understand the pathogenesis and optimize treatment strategies for osseous sarcoidosis.