QT interval prolongation associated with low magnesium in chronic alcoholics

Alcoholism is a psychoactive drug-dependence with high prevalence throughout the world. Alcoholism has already been shown to be associated with electrical heart disorders, such as QT interval prolongation. Long QT, rare among healthy individuals (0.0017-0.31%), can trigger tachyarrhythmias and sudden death and might be caused by alcohol consumption itself and the resulting hypomagnesaemia.

This case-control study assessed active alcoholics and alcoholics who have been abstinent for at least seven days to compare changes in electrocardiographic, clinical and laboratory analyses among groups.

A total of 166 alcoholics were evaluated, of which 62 were active and 104 abstinent alcoholics. Long QT was more prevalent among active alcoholics compared to abstinent alcoholics (16% vs. 2%, respectively, odds ratio (OR) 9.81, p=0.011), as was hypomagnesaemia (23% vs. 10%, OR 3.11, p=0.013). Serum magnesium levels were inversely proportional to the length of the corrected QT interval among active alcoholics (β=-35.1ms, p=0.005).

Active chronic alcoholics exhibited a higher association of long QT and hypomagnesaemia. Low serum magnesium levels were predictive of QT interval prolongation. Because the above changes potentially trigger fatal arrhythmias, it is of fundamental importance to consider the diagnostic possibility by routinely requesting electrocardiograms and serum magnesium level assessment during the treatment of chronic alcoholic patients.