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Stem Cells: Potential Therapy for Neonatal Injury?
Momoko Yoshimoto1, Joyce M Koenig2
1Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, R4-W116, Indianapolis, IN 46202, USA.
Clinics in Perinatology
|August 8, 2015
Summary
Stem cell transplantation (SCT) shows promise for treating neonatal diseases. Emerging evidence suggests SCT can protect the brain and reduce inflammation in at-risk newborns following injury.
Area of Science:
- Neonatal medicine
- Stem cell biology
- Neuroscience
Background:
- Stem cell transplantation (SCT) is a recognized therapy for various diseases in neonates and adults.
- Preclinical and limited human studies indicate SCT's potential for neuroprotection and anti-inflammatory effects in neonates.
Purpose of the Study:
- To review human stem cell biology during development.
- To present evidence supporting SCT for neonatal post-insult injury.
Main Methods:
- Review of current literature on stem cell biology.
- Synthesis of recent research on SCT in neonatal injury models and human studies.
Main Results:
- Stem cell biology during ontogeny is complex and crucial for therapeutic potential.
- Evidence supports SCT's efficacy in neuroprotection and modulating inflammatory responses in at-risk neonates.
Conclusions:
- Stem cell transplantation is a promising therapeutic strategy for neonatal diseases.
- Further research into SCT for post-insult neonatal injury is warranted.
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