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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Hematopoietic stem cell-independent and -dependent hematopoiesis: new insights and lineage-tracing methods

Miguel Ganuza1, Momoko Yoshimoto2

  • 1Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.

Experimental Hematology
|December 15, 2025
PubMed

Recent advances in developmental hematology have revealed unappreciated hematopoietic waves and origins during development, and unexpected hematopoietic stem cell (HSC)-independent progenitors that provide lifelong hematopoiesis, using in vivo barcoding technologies and various lineage-tracing mouse models. Also, these tools estimate HSC numbers and display HSC behaviors that have not been anticipated. This review introduces such new discoveries in blood development and discusses the data and controversies.

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