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Ivermectin: A Review in Rosacea.

Emma D Deeks1

  • 1Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand. demail@springer.com.

American Journal of Clinical Dermatology
|August 9, 2015
PubMed
Summary

Ivermectin 1% cream offers an effective, well-tolerated, once-daily treatment for moderate to severe rosacea. Clinical trials show it improves symptoms and quality of life compared to vehicle and metronidazole cream.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Rosacea is a chronic inflammatory skin condition affecting the face.
  • Current treatments aim to reduce inflammation and lesions.
  • Ivermectin 1% cream is a novel topical agent for rosacea treatment.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of ivermectin 1% cream for rosacea.
  • To compare ivermectin 1% cream with vehicle and metronidazole cream.

Main Methods:

  • Phase III, 12- or 16-week trials in adults with moderate to severe papulopustular rosacea.
  • Once-daily application of ivermectin 1% cream versus vehicle.
  • Comparison with twice-daily metronidazole 0.75% cream.

Main Results:

  • Ivermectin 1% cream significantly improved rosacea symptoms and quality of life versus vehicle.
  • It demonstrated superior efficacy to metronidazole 0.75% cream.
  • Long-term (up to 52 weeks) treatment showed sustained benefit.
  • Adverse events like skin burning and irritation were infrequent (<2%).

Conclusions:

  • Ivermectin 1% cream is an effective and well-tolerated topical treatment for inflammatory rosacea.
  • Its once-daily application offers convenience for patients.
  • It represents a valuable therapeutic option for managing rosacea.

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