Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure of Blood Vessels01:15

Structure of Blood Vessels

11.3K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
11.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Nanodots and Their Performance in Powder and Coated Fabrics Forms for Industrial Wastewater Treatment.

Water environment research : a research publication of the Water Environment Federation·2026
Same author

Advances in antimicrobial orthopaedic devices and FDA regulatory challenges.

Progress in biomedical engineering (Bristol, England)·2024
Same author

Review on Engineering of Bone Scaffolds Using Conventional and Additive Manufacturing Technologies.

3D printing and additive manufacturing·2024
Same author

Carbon dioxide-activated mesoporous date palm fronds carbon integrated with MnO<sub>2</sub>/polyaniline for highly efficient capacitive deionization of water.

Water environment research : a research publication of the Water Environment Federation·2024
Same author

Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors.

Advanced functional materials·2023
Same author

Preparation of Polylactic Acid/Calcium Peroxide Composite Filaments for Fused Deposition Modelling.

Polymers·2023

Related Experiment Video

Updated: Apr 5, 2026

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.5K

A multilayered microfluidic blood vessel-like structure.

Anwarul Hasan1, Arghya Paul, Adnan Memic

  • 1Biomedical Engineering, and Department of Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, 1107 2020, Lebanon, mh211@aub.edu.lb.

Biomedical Microdevices
|August 11, 2015
PubMed
Summary
This summary is machine-generated.

Researchers developed a new microfluidic method using photocrosslinkable gelatin hydrogel to create multi-layered, biomimetic blood vessel structures. This rapid technique enables precise control over vessel dimensions for applications in disease modeling and drug screening.

More Related Videos

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
07:05

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

15.1K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.8K

Related Experiment Videos

Last Updated: Apr 5, 2026

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.5K
Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
07:05

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

15.1K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.8K

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Microfluidics

Background:

  • Significant demand exists for engineered blood vessels.
  • Current methods struggle to replicate native vessel complexity, particularly multi-layered walls.
  • Perfusable, biomimetic vascular structures are crucial for advanced biomedical applications.

Purpose of the Study:

  • To present a novel microfluidic fabrication method for creating tri-layer biomimetic blood vessel-like structures.
  • To enable independent control over vessel diameter, wall thickness, and individual layer thickness.
  • To establish a rapid and versatile platform for vascular tissue engineering.

Main Methods:

  • Utilized photocrosslinkable gelatin hydrogel on a microfluidic platform.
  • Developed a fabrication process allowing for mono-, bi-, or tri-layer vascular walls.
  • Achieved physical fabrication of vascular structures within minutes.

Main Results:

  • Successfully fabricated physiological blood vessel-like structures with controllable dimensions.
  • Demonstrated independent control over vessel diameter and wall layer thicknesses.
  • Achieved formation of an internal vascular endothelial cell layer within 3-5 days.

Conclusions:

  • The developed method offers a simple, rapid, and controllable approach for fabricating multi-layered vascular constructs.
  • These engineered vessels hold potential for drug screening, in vitro disease modeling (cardiovascular, cancer metastasis), and vascular biology studies.
  • This platform advances the field of tissue engineering by providing biomimetic perfusable vascular structures.