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Elevated serum ghrelin, tumor necrosis factor-α and interleukin-6 in congenital heart disease

Dandan Wang1, Jian Fang2, Ruigeng Wang1

  • 1Department of Cardiovascular Medicine, Wuhan Women and Children's Health Care Center, Wuhan, China.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 11, 2015
PubMed

Insights

Congenital heart disease (CHD) in children is associated with elevated levels of serum ghrelin, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). These biomarkers may contribute to the development and progression of CHD.

Area of Science:

  • Pediatric Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Congenital heart disease (CHD) is a significant health concern in pediatric populations.
  • Understanding the underlying pathophysiological mechanisms of CHD is crucial for effective management.
  • Investigating novel biomarkers associated with CHD can provide insights into disease development.

Purpose of the Study:

  • To examine the relationship between congenital heart disease (CHD) and serum levels of ghrelin, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in children.
  • To compare these biomarker levels between children with CHD and healthy controls.
  • To explore potential correlations between these biomarkers and anthropometric measurements in children with CHD.

Main Methods:

  • A case-control study involving 63 children with CHD and 28 healthy controls.
  • Serum concentrations of ghrelin, TNF-α, and IL-6 were measured using Enzyme-linked immunosorbent assay (ELISA).
  • Statistical analysis included variance analysis, Pearson correlation, and meta-analysis using SPSS and Comprehensive Meta-analysis software.

Main Results:

  • Children with CHD (both cyanotic and acyanotic) exhibited significantly higher serum levels of ghrelin, TNF-α, and IL-6 compared to healthy controls.
  • Significant differences in weight, height, and body mass index (BMI) were observed between CHD groups and controls.
  • Ghrelin correlated positively with BMI, while TNF-α showed a negative correlation and IL-6 a positive correlation with BMI.

Conclusions:

  • Elevated serum ghrelin, TNF-α, and IL-6 are characteristic of congenital heart disease in children.
  • These elevated biomarkers may play a role in the pathogenesis and progression of CHD.
  • Further research is warranted to elucidate the precise mechanisms by which these factors influence CHD.
Abstract

Keywords:
acyanotic congenital heart diseasecongenital heart diseasecyanotic congenital heart diseaseghrelininterleukin-6tumor necrosis factor-α

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