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Hepatitis E seroprevalence in inflammatory bowel disease
Carla Senosiain1, Ana González-Tallón A1, Antonio López-Sanromán1
1IBD Clinic, Gastroenterology Department, Hospital "Ramón y Cajal", E28034 Madrid, Spain.
Gastroenterologia Y Hepatologia
|August 11, 2015
Summary
Hepatitis E virus (HEV) seroprevalence in inflammatory bowel disease (IBD) patients is low, similar to the general population. No chronic HEV infections were detected in this immunocompromised group.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Immunology
Background:
- Patients with inflammatory bowel disease (IBD) often experience compromised immunity due to the condition or its treatments.
- Recent reports highlight chronic hepatitis E virus (HEV) infections in immunocompromised individuals.
Purpose of the Study:
- To assess HEV seroprevalence among IBD patients.
- To identify potential chronic HEV infections within this cohort.
Main Methods:
- A prospective study of 87 IBD patients from a Madrid clinic.
- Epidemiological interviews, serological testing for anti-HEV IgG/IgM, and HEV-RNA detection.
- Review of medical records for immunosuppressive drug exposure.
Main Results:
- The study included 87 IBD patients (mean age 44.7 years, mean IBD duration 10.4 years).
- HEV seroprevalence was low: 2.7% for IgM and 1.3% for IgG.
- No HEV-RNA was detected, indicating no chronic HEV infections.
Conclusions:
- HEV seroprevalence in IBD patients is low (1.14%), comparable to the general population.
- This may be attributed to a lesser degree of immunosuppression or distinct dietary patterns in this group.
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