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Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Updated: Jun 24, 2026

A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography
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A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography

Published on: July 21, 2023

COMPARING NAFLD, MAFLD, AND MASLD CRITERIA FOR IDENTIFYING SIGNIFICANT LIVER FIBROSIS: A CROSS-SECTIONAL STUDY.

Hung Cao Dinh1, Tuong Thi Khanh Tran1, Hoang Huu Nguyen2

  • 1Pham Ngoc Thach University of Medicine, Vietnam.

Gastroenterologia Y Hepatologia
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

The metabolic dysfunction-associated fatty liver disease (MAFLD) criteria capture more patients with significant liver fibrosis compared to NAFLD/MASLD, especially those with dual etiologies like viral hepatitis or alcohol use.

Keywords:
MAFLDMASLDNAFLDVietnamelastografía transitoriafibrosis hepáticaliver fibrosistransient elastography

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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

Area of Science:

  • Hepatology
  • Diagnostic criteria evaluation
  • Liver disease epidemiology

Background:

  • Diagnostic frameworks for fatty liver disease, including non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and metabolic dysfunction-associated fatty liver disease (MAFLD), have differing implications.
  • Debate exists regarding these frameworks, particularly in populations with high rates of viral hepatitis and alcohol use.
  • This study addresses the diagnostic concordance and fibrosis detection across these frameworks in a Vietnamese cohort.

Purpose of the Study:

  • To evaluate diagnostic concordance among NAFLD, MASLD, and MAFLD criteria.
  • To compare the detection of liver fibrosis across these diagnostic frameworks.
  • To investigate the implications of different criteria in a Vietnamese population with potential dual etiologies.

Main Methods:

  • A cross-sectional study involving 360 adults.
  • Liver fibrosis and steatosis assessed using transient elastography (TE) with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP).
  • Patients classified under NAFLD, MASLD, and MAFLD criteria; logistic regression used to identify factors associated with significant fibrosis.

Main Results:

  • A significant overlap was observed, with 76.67% meeting all three definitions; however, 15.83% met only MAFLD criteria.
  • The MAFLD group exhibited higher liver stiffness (median 5.0 kPa) compared to the non-MAFLD group (median 4.1 kPa; p=0.004).
  • Multivariable analysis showed an inverse association between NAFLD/MASLD and significant fibrosis (OR=0.418, p<0.05), while MAFLD had a non-significant positive association (OR=1.347, p=0.791), indicating MAFLD includes dual-etiology cases.

Conclusions:

  • NAFLD and MASLD criteria may underestimate fibrosis risk by excluding patients with coexisting metabolic dysfunction and viral or alcohol-related liver disease.
  • MAFLD criteria encompass these dual-etiology cases, reflecting a more heterogeneous and potentially higher-risk patient profile.
  • The MAFLD framework may offer a more comprehensive approach to identifying individuals with significant liver fibrosis in diverse etiological settings.