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Acute Pancreatitis Unmasking Primary Hyperparathyroidism: A Case Report.
Hung Cao Dinh1,2,3, Khanh Quang Tran3,4, Dung Manh Doan4
1Faculty of Medicine, Department of Internal Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
AACE Endocrinology and Diabetes
|July 18, 2025
Summary
Primary hyperparathyroidism (PHPT) can cause acute pancreatitis (AP). Evaluating serum calcium is crucial for diagnosing PHPT in patients with recurrent AP, leading to effective parathyroidectomy treatment.
Area of Science:
- Endocrinology
- Gastroenterology
Background:
- Primary hyperparathyroidism (PHPT) is characterized by elevated parathyroid hormone, causing hypercalcemia and potential complications.
- Acute pancreatitis (AP) is an uncommon but serious manifestation of hypercalcemia linked to PHPT.
Observation:
- A 56-year-old woman presented with recurrent AP, with initial workups for common causes yielding negative results.
- Persistent hypercalcemia and elevated parathyroid hormone levels confirmed PHPT due to a parathyroid adenoma.
Findings:
- Parathyroidectomy resolved the patient's symptoms and normalized serum calcium levels.
- The case highlights PHPT as a potential cause of AP, even with normal or mildly elevated calcium.
Implications:
- PHPT should be considered in unexplained recurrent AP cases.
- Serum calcium assessment is vital for diagnosing hypercalcemia-induced AP.
- Parathyroidectomy offers definitive treatment for PHPT-related AP.
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