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Updated: Apr 5, 2026

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Published on: March 28, 2016

Investigating neuronal function with optically controllable proteins.

Xin X Zhou¹, Michael Pan², Michael Z Lin³

¹Department of Bioengineering, Stanford University Stanford, CA, USA.

Frontiers in Molecular Neuroscience

|August 11, 2015

Summary

This summary is machine-generated.

Optical control of protein activity using photosensory domains offers precise regulation of neuronal functions. This technology revolutionizes the study of intracellular signaling in the brain.

Keywords:

development optobiology optogenetics signal transduction transcription

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Last Updated: Apr 5, 2026

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Published on: March 28, 2016

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A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

Area of Science:

Neuroscience
Molecular Biology
Cell Biology

Background:

Protein activity in the nervous system is precisely regulated in space and time.
This regulation is crucial for neuronal development, structure, and function.
Localized and transient protein activation underlies processes like neurite extension and synaptogenesis.

Purpose of the Study:

To review methods for optically controlling protein activity.
To highlight the application of photosensory domains in neuroscience.
To discuss the potential of optical control for studying intracellular signaling.

Main Methods:

Utilizing photosensory domains to achieve light-inducible protein activity modulation.
Applying these optogenetic tools to investigate protein regulation in neuronal processes.
Reviewing existing literature on optical control strategies in neuroscience.

Main Results:

Photosensory domains enable versatile optical control over diverse proteins and cellular functions.
These tools allow for localized and transient modulation of protein activity.
Demonstrated potential for studying complex cellular mechanisms in the nervous system.

Conclusions:

Optical control of protein activity is a powerful tool for neuroscience research.
Photosensory domain-based methods offer unprecedented precision in studying intracellular signaling.
This approach holds significant promise for future discoveries in brain circuitry and function.