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Dynamic potential and surface morphology study of sertraline membrane sensors
M M Khater1, Y M Issa1, H B Hassib1
1Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Journal of Advanced Research
|August 11, 2015
Summary
A new electrometric method using heteropolyacid-based membrane sensors offers a rapid and sensitive way to determine sertraline hydrochloride (Ser-Cl) in raw materials and formulations. This advancement provides a simple yet effective analytical tool for quality control.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Materials Science
Background:
- Accurate determination of active pharmaceutical ingredients like sertraline hydrochloride is crucial for drug quality and patient safety.
- Existing analytical methods may lack the desired speed, sensitivity, or simplicity for routine quality control.
- Development of novel electrochemical sensors can address these limitations.
Purpose of the Study:
- To develop a new, rapid, sensitive, and simple electrometric method for determining sertraline hydrochloride (Ser-Cl).
- To prepare and characterize novel membrane sensors utilizing heteropolyacids as ion-associating materials.
- To evaluate the performance of these sensors in analyzing Ser-Cl in pure form and pharmaceutical formulations.
Main Methods:
- Fabrication of membrane sensors incorporating silicomolybdic acid (SMA), silicotungstic acid (STA), and phosphomolybdic acid (PMA) as ion-associating materials.
- Electrochemical characterization of the sensors, including determination of slope and limit of detection.
- Application of the sensors for potentiometric titration of Ser-Cl using sodium tetraphenylborate.
- Surface morphology analysis using scanning and atomic force microscopy.
Main Results:
- Successfully developed three types of membrane sensors (Ser-ST, Ser-PM, Ser-SM) for Ser-Cl determination.
- Achieved high sensitivity with limits of detection as low as 2.51 μmol L⁻¹ (Ser-ST).
- Demonstrated a wide linear range (0.01-10.00) for all three sensors.
- Confirmed the utility of the sensors in potentiometric titrations and analyzed membrane surface characteristics.
Conclusions:
- The developed heteropolyacid-based membrane sensors provide a rapid, sensitive, and simple electrometric method for sertraline hydrochloride quantification.
- These sensors are suitable for determining Ser-Cl in both raw materials and pharmaceutical formulations, offering a viable alternative to conventional methods.
- The study highlights the potential of these novel sensors in pharmaceutical analysis and quality control.
