Novel hematologic inflammatory parameters to predict acute mesenteric ischemia.

Area of Science:

• Medical diagnostics
• Inflammatory biomarkers
• Gastrointestinal emergencies

Background:

• Acute mesenteric ischaemia (AMI) is a life-threatening condition necessitating prompt diagnosis.
• Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are established inflammatory markers, but their role in AMI requires further investigation.

Purpose of the Study:

• To evaluate the diagnostic utility of NLR and PLR as inflammatory biomarkers in patients with AMI.
• To compare NLR, PLR, and C-reactive protein (CRP) levels in AMI patients versus healthy controls.

Main Methods:

• A case-control study involving 46 AMI patients and 46 matched healthy controls.
• Diagnosis of AMI was confirmed using computed multidetector tomographic angiography.
• NLR, PLR, and CRP levels were determined from complete blood counts and serum analysis.

Main Results:

• Patients with AMI exhibited significantly higher NLR (P < 0.001) and PLR (P = 0.039) compared to controls.
• Elevated C-reactive protein (CRP) levels were observed in AMI patients.
• NLR and PLR demonstrated a positive correlation with CRP levels.
• An NLR threshold of 4.5 showed 77% sensitivity and 72% specificity for AMI diagnosis.

Conclusions:

• Increased NLR, PLR, and CRP levels are associated with AMI.
• NLR and PLR serve as valuable independent predictors for the diagnosis of acute mesenteric ischaemia.