Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV...

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) is a rare non-Hodgkin lymphoma.
• Understanding prognostic factors is crucial for patient management and treatment strategies.

Purpose of the Study:

• To investigate the clinicopathological features and prognostic factors of PI-DLBCL in Taiwan.
• To compare PI-DLBCL characteristics in Taiwan with other geographic regions.

Main Methods:

• Retrospective analysis of 59 surgically resected PI-DLBCL cases.
• Evaluation of clinical data, including perforation, tumor location, treatment received, and survival rates.
• In situ hybridization for Epstein-Barr virus (EBV) and fluorescence in situ hybridization (FISH) for gene rearrangements (IGH, BCL2, BCL6, MYC).

Main Results:

• Ileum and ileocecum were the most frequent sites.
• Perforation at presentation occurred in 19% of cases.
• One-, 2-, and 5-year overall survival rates were 68.4%, 56.5%, and 50.0%, respectively.
• Perforation, high ECOG Performance Status (PS), and absence of adjuvant chemotherapy were poor prognostic factors.
• Taiwanese PI-DLBCL showed higher perforation rates, lower germinal center B-cell phenotype frequency, and higher EBV association compared to other regions.

Conclusions:

• Perforation and lack of chemotherapy are significant independent poor prognostic factors for PI-DLBCL.
• PI-DLBCL in Taiwan presents distinct features compared to other populations.
• Further research is needed to optimize treatment strategies for PI-DLBCL, especially in cases with perforation.