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Updated: Apr 5, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Two Pairs of Enantiomeric Alkaloid Dimers from Macleaya cordata
Chun-Mei Sai, Da-Hong Li, Chun-Mei Xue
1‡Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, United States.
Abstract:
Two pairs of enantiomeric alkaloid dimers, (±)-macleayins A (1) and B (2), representing a novel dimerization pattern of two different types of alkaloids via a C-C σ-bond, were isolated from the aerial parts of Macleaya cordata. The enantiomeric separation was achieved by chiral chromatography. Their structures and stereochemistry were determined by the analysis of extensive spectroscopic data, electronic circular dichroism calculation, and single-crystal X-ray diffraction data. (-)-Macleayin A exhibits modest cytotoxic activity against HL-60 cell line with the IC50 value of 3.51 μM.
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