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Related Experiment Videos

Structure of the sheep epidermis.

D H Lloyd, S F Amakiri, D M Jenkinson

    Research in Veterinary Science
    |March 1, 1979
    PubMed
    Summary

    The stratum corneum, the skin's outer layer, is thicker than previously thought and uniformly permeated with sebum. This finding impacts our understanding of skin barrier function and topical agent penetration.

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    Area of Science:

    • Dermatology
    • Skin Biology
    • Histology

    Background:

    • The stratum corneum is the outermost layer of the epidermis, crucial for skin barrier function.
    • Previous studies have reported varying thicknesses of the stratum corneum.
    • Understanding the stratum corneum's structure is vital for dermatological research and treatment.

    Purpose of the Study:

    • To accurately measure the thickness of the stratum corneum in fresh frozen sections.
    • To investigate the distribution and role of sebum in the stratum corneum.
    • To compare the thickness of the stratum corneum with the underlying living epidermis.

    Main Methods:

    • Histological examination of fresh frozen skin sections.
    • Microscopic measurement of stratum corneum thickness.
    • Assessment of sebum permeation and surface film formation.

    Main Results:

    • The stratum corneum was found to be considerably thicker than previously reported in fresh frozen sections.
    • Uniform permeation of sebum throughout the stratum corneum was observed.
    • Sebum also formed an intact film on the skin surface.
    • The living epidermis was approximately half the thickness of the stratum corneum.

    Conclusions:

    • The stratum corneum possesses a greater thickness and a more significant role of sebum than previously documented.
    • These findings necessitate a re-evaluation of models describing skin barrier function.
    • Further research is warranted to explore the implications for percutaneous absorption and dermatological therapies.

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