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Antitumor efficacy of extracellular complexes with gadolinium in Binary Radiotherapy
A A Lipengolts1, A A Cherepanov1, V N Kulakov2
1Blokhin Russian Cancer Scientific Centre, Kashirskoe sh. 24, Moscow, Russian Federation; Burnasyan Federal Medical Biophysical Centre, Zhivopisnaya 46, Moscow, Russian Federation; National Research Nuclear University "MEPhI", Kashirskoe sh. 31, Moscow, Russian Federation.
Abstract:
In this report the efficacy of extracellular pharmaceutical Gd-DTPA in Binary Radiotherapy was studied. The study was carried out in mice bearing transplantable adenocarcinoma Ca755 using X-ray based contrast enhanced radiotherapy as a practical implementation of Binary Radiotherapy. It was shown that intravenous administration of 0.3 ml of 0.5 M water solution of Gd-DTPA followed by X-irradiation at a dose of 10 Gy provides T/C%=10±3% and leads to complete tumor regression in 25% of mice.
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