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Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
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Visceral Obesity Is Associated with Gallbladder Polyps.
Jun Kyu Lee1, Suk Jae Hahn1, Hyoun Woo Kang1
1Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
Gut and Liver
|August 12, 2015
Summary
Visceral obesity, measured by visceral adipose tissue (VAT) and total adipose tissue (TAT), is a significant risk factor for gallbladder polyps (GBP). This finding holds true regardless of body mass index or waist circumference.
Area of Science:
- Gastroenterology
- Radiology
- Obesity Medicine
Background:
- Gallbladder polyps (GBP) are common and can be precancerous.
- The relationship between visceral obesity and GBP requires further investigation.
Purpose of the Study:
- To determine if visceral obesity is a risk factor for gallbladder polyps (GBP).
Main Methods:
- Retrospective review of 1,615 subjects undergoing ultrasonography and computed tomography.
- Measurement of visceral adipose tissue (VAT) and total adipose tissue (TAT) areas.
- Comparison of 93 subjects with GBP against 186 matched controls.
Main Results:
- Visceral adipose tissue (VAT) and total adipose tissue (TAT) were independent risk factors for GBP.
- Higher quartiles of VAT and TAT showed significant odds ratios for GBP.
- Hypertension, diabetes mellitus, hepatitis B virus positivity, and high total cholesterol also correlated with GBP.
Conclusions:
- Visceral obesity, quantified by VAT and TAT, is independently associated with gallbladder polyps.
- This association persists irrespective of body mass index (BMI) or waist circumference.
- Visceral fat measurement offers valuable insight into GBP risk.
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