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Tuberculosis (HIV-negative people): improving adherence
Liliya Eugenevna Ziganshina1, Michael Eisenhut
1Kazan Federal University, Kazan, Russia.
BMJ Clinical Evidence
|August 12, 2015
Summary
This systematic overview evaluated directly observed treatment (DOT) versus self-administered treatment (SAT) for tuberculosis (TB). It categorized the efficacy of 13 interventions for TB treatment effectiveness and safety.
Area of Science:
- Public Health
- Infectious Diseases
- Clinical Medicine
Background:
- Tuberculosis (TB) affects approximately one-third of the global population.
- In 2013, TB caused 9.0 million new cases and 1.5 million deaths worldwide.
- Research is crucial to optimize TB treatment strategies.
Purpose of the Study:
- To systematically review the effectiveness and safety of directly observed treatment (DOT) compared to self-administered treatment (SAT) for tuberculosis patients without HIV.
- To assess the impact of support mechanisms for DOT in tuberculosis management.
- To answer key clinical questions regarding TB treatment efficacy.
Main Methods:
- A systematic overview was conducted, searching major databases including Medline, Embase, and The Cochrane Library up to June 2014.
- 189 studies were initially retrieved, with 104 records screened after deduplication.
- 18 full publications were evaluated, including three new systematic reviews and one RCT, with a GRADE evaluation for 12 PICO combinations.
Main Results:
- The overview identified and evaluated evidence for 13 interventions related to TB treatment.
- Data focused on the effectiveness and safety of DOT and its support mechanisms.
- GRADE methodology was applied to assess the quality of evidence.
Conclusions:
- The study categorized the efficacy of 13 interventions for tuberculosis treatment.
- Findings provide insights into the effectiveness and safety of directly observed treatment and its support mechanisms.
- This systematic overview contributes to understanding optimal TB care strategies.
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