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Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Hyperbilirubinaemia and erythrocytic glucose 6 phosphate dehydrogenase deficiency in Malaysian children

A T Hon, S Balakrishnan, Z Ahmad

    The Medical Journal of Malaysia
    |March 1, 1989
    PubMed

    Insights

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency occurred in 4.5% of Chinese, 3.5% of Malay, and 1.5% of Indian newborns. Some infants with G6PD deficiency experienced severe hyperbilirubinemia requiring readmission.

    Area of Science:

    • Neonatal Medicine
    • Pediatrics
    • Genetics

    Background:

    • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited condition.
    • Neonatal hyperbilirubinemia is a frequent complication in infants with G6PD deficiency.

    Purpose of the Study:

    • To determine the incidence of G6PD deficiency in newborns in Johor Bahru.
    • To investigate the clinical course of hyperbilirubinemia in G6PD-deficient infants.

    Main Methods:

    • Screening of cord blood samples from 8,975 neonates for G6PD deficiency.
    • Monitoring serum bilirubin levels in 100 neonates for seven days.
    • Observing readmission rates for hyperbilirubinemia in G6PD-deficient infants.

    Main Results:

    • Overall G6PD deficiency incidence: 4.5% (Chinese), 3.5% (Malays), 1.5% (Indian).
    • Serum bilirubin peaked at 12mg% around 96 hours in observed neonates.
    • Six G6PD-deficient infants were readmitted due to hyperbilirubinemia requiring exchange transfusion.

    Conclusions:

    • G6PD deficiency has a variable incidence across ethnic groups in this population.
    • Neonatal hyperbilirubinemia in G6PD-deficient infants can be severe, necessitating close monitoring and intervention.

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